December 28, 2008

Positivity: Researchers See Adult Stem Cell Progress; They Self-Renew, Repair Tissue

Filed under: Life-Based News,Positivity — Tom @ 6:59 am

From Stanford, California, via Life News:

Two groups of researchers have made more progress with the use of adult stem cells — showing they are both more ethical and more effective than their embryonic counterparts. In this latest find, they demonstrated that adult stem cells can self renew and repair tissue damage.

Stanford University scientists issued a report at the 48th annual meeting of the American Society for Cell Biology (ASCB) on Sunday.

They transplanted the skeletal adult muscle stem cells into special immune-suppressed mice whose muscle satellite cells had been wiped out in a hind limb by irradiation. The stem cells restored lost function to mice with hind limb muscle tissue damage.

The team used luminescent imaging as well as quantitative and kinetic analyses to track each transplanted stem cell as it rapidly proliferated and engrafted its progeny into the irradiated muscle tissue.

The scientists then injured the regenerated tissue, setting off muscle cell growth and repair, and subsequently showed that the muscle stem cells and descendents rescued the second animal’s lost muscle healing function.

After isolating the luciferase-glowing muscle stem cells from the transplanted animal, the scientists cloned the cells in the lab. Like the original muscle cells, the cloned copies were intact and capable of self renewal.

After demonstrating that the transplanted stem cells proliferated and fully restored the animal’s lost function, the scientists recovered new stem cells from the transplant with full stem cell potency.

Dr. David Prentice, a former Indiana State University biology professor who is a leading pro-life bioethicist, told LifeNews.com he is excited about the news.

“The work by the Stanford group is exciting, because it shows with very definitive experiments that even a single muscle adult stem cell can grow and repair muscle damage, while still maintaining a pool of muscle stem cells for future repair, or as in these experiments, for transplant,” he explained. …..

Go here for the rest of the story.

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